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my personal edition > dermatitis > news
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DGReview
Link Found Between Vitamin E Intake and Immunoglobulin E In Treatment Of Atopic Dermatitis
A DGReview of :"Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels"
International Journal of Dermatology
05/31/2002
By David Ball
Dietary vitamin E (VE) could be an excellent tool in treating atopic dermatitis, say researchers.
Their single-blind clinical analysis of 96 subjects with atopic dermatitis found a correlation between VE intake, levels of immunoglobulin E (IgE) and clinical manifestations of atopy.
The effects on subjective symptoms and serum IgE levels of oral VE intake were compared with those of placebo (PL) by dermatologists from the University of Siena, Italy, Charles University, Prague, Czech Republic, and University of Florence, Italy.
Fifty randomised subjects were given once a day, for eight months, 400 IU (268 mg) of VE of natural origin while 46 took PL.
On enrolment, and every 15 days throughout the study, tests were made for complete blood count, serum IgE levels, radioallergosorbent test (RAST) score, antinuclear antibodies (ANA), and biochemical analysis.
Four VE subjects worsened and six showed no change compared with 36 and five, respectively, in the PL group.
Ten VE subjects showed slight improvement compared to four in the PL group and great improvement was seen in 23 VE subjects with just one in the PL group.
While almost complete remission was achieved by five females and two males in the VE group, there was none in PL subjects. Females also showed less progression of atopic dermatitis than males in both groups.
During the study there was marked variation in the range of serum IgE levels, from 1005 to 490 IU/mL in VE subjects and from 1239 to 812 IU/mL in PL.
VE subjects who showed great improvement and near remission had a decrease of 62 in serum IgE levels based on initial conditions while the difference was around 34.4 for PL subjects.
Neither group showed complications and the presence of apparently normal skin was reported along with remarkable improvement in facial erythema and lichenification.
International Journal of Dermatology 41 (3), 146-150.
"Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels"
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