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Nasal Provocation Test Helps Diagnose Aspirin-Induced Asthma
A DGReview of :"Nasal provocation test (NPT) with aspirin: a sensitive and safe method to diagnose aspirin-induced asthma (AIA)"
Allergy
07/08/2002
By Elda Hauschildt
A nasal provocation test has both high sensitivity and specificity in diagnosing aspirin-induced asthma (AIA).
Spanish researchers report an 84.2 percent positive predictive value in using nasal provocation testing in 60 patients and a predictive value of 89.2 percent.
Investigators with the allergy department at the Hospital Clinico San Carlos in Madrid suggest oral provocation can be used to confirm the results whenever the clinical situation permits.
They studied 20 AIA patients and 40 aspirin-tolerant patients, confirming aspirin tolerance through oral provocation in 10 asthmatic patients and 30 healthy people.
The nasal provocation test was done with lysine acetylsalicylic acid (L-ASA).
The researchers monitored nasal and pulmonary functions in participants using anterior active rhinomanometry and spirometry. They administered four increasing doses of ASA with saline solution control, controlling for nasal inspiratory peak flow and expiratory peak flow.
Patients had no bronchial or systemic symptoms, the investigators note and there were no decreases in forced expiratory volume in one second greater than 20 percent among participants.
Allergy, 2002; 57: 632-635.
"Nasal provocation test (NPT) with aspirin: a sensitive and safe method to diagnose aspirin-induced asthma (AIA)"
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