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Silicone-Related Symptoms Increase One Year Following Breast Implant
A DGReview of :"A Prospective Study on Silicone Breast Implants and the Silicone-Related Symptom Complex"
Clinical Rheumatology
07/23/2002
By Anne MacLennan
Complaints from women of silicone-related symptoms, particularly Sjogren's and RA/Raynaud's, increase in the year after breast implantation.
This elevated expression of silicone-related symptom complex (SRSC) one year after immediate breast reconstruction (IBR) is not linked with changes either in the presence of antinuclear antibodies (ANA) or in magnetic resonance imaging (MRI) of the silicone breast implant (SBI).
These are the findings of a prospective study by Dr C. M. E. Contant and colleagues from the University Hospital Rotterdam/Daniel den Hoed Cancer Centre, and the Medisch Centrum Rijnmond Zuid, both in Rotterdam, The Netherlands.
Fifty-seven women undergoing mastectomy followed by IBR and SBI participated in this evaluation of the prevalence of SRSC in relation to ANA and MRI of the implants one year after the procedure.
The sera of the women were tested before and then one year after IBR for ANA, and the women were screened by questionnaire for prevalence of SRSC-related symptoms. Doctors evaluated all prostheses by MRI one month and one year after IBR.
Immediately prior to the surgery, 11 percent of the women had a Sjogren score of more than two, whereas one year later, 30 percent of them had this same score after IBR.
One year after surgery, RA/Raynaud-related complaints also rose significantly, from 21 percent preoperatively to 40 percent one year after IBR.
In the undefined complaints-related group, 19 percent of the women had a score of two or more preoperatively versus 33 percent at year one post-IBR.
There were no new cases of ANA positivity at the end of the year.
The MRI noted the linguine sign in three implants: one at one month after IBR and two at one year after IBR. These MRI findings were not linked to changes in SRSC expression.
Clinical Rheumatology Volume 21 Issue 3 (2002) pp 215-219.
"A Prospective Study on Silicone Breast Implants and the Silicone-Related Symptom Complex"
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