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Estrogen Receptor Beta Gene May Modulate Early Bone Metabolism
Eine DGReview von : "Estrogen receptor beta gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women"
Bone
08/13/2002
By Anne MacLennan
Estrogen receptor beta gene polymorphisms are linked with higher bone mineral density in premenopausal but not in postmenopausal women.
This finding in a study among 325 healthy southern Chinese women raises the possibility the estrogen receptor beta (ERbeta) gene plays a modulatory role in bone metabolism in young adults, suggest Dr. H. H. Lau and colleagues from the University of Hong Kong, Queen Mary Hospital, Hong Kong.
Bone mineral density (BMD), the main determining risk factor for osteoporotic fractures, has a strong genetic component; estrogen and its receptors are key in both skeletal maturity and bone loss.
Thus, these researchers investigated the link between BMD and dinucleotide (cytosine-adenine; CA) repeat polymorphisms in the flanking region of the ERbeta gene in these women, 120 of them premenopausal and 205 postmenopausal.
BMD was measured at the lumbar spine and hip region via dual-energy X-ray absorptiometry (DEXA). The number of the repeats among the women ranged from 16 to 28.
After researchers took into account the women's age, height, weight and years of estrogen exposure, premenopausal subjects with at least one allele of 20 CA repeats were found to have significantly higher BMD at the L2-4 lumbar spine, total hip, femoral neck, trochanter and Ward's triangle.
In these premenopausal women, with or without 20 CA repeats, there was no difference in the vertebral area of L-3 and femoral neck width.
In postmenopausal women, however, ERbeta gene polymorphisms were not related to BMD at any skeletal site.
Thus, ERbeta gene polymorphisms are linked with higher BMD in premenopause, suggesting this gene may have a modulatory role in bone metabolism in young adulthood, these authors conclude.
Bone 2002 Aug;31(2):276-81.
"Estrogen receptor beta gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women"
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