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Fibrogenic Cytokines May Play Role in Nephrogenic Fibrosing Dermatopathology: Presented at ASDP
By Alison Palkhivala
Special to DG News
PHOENIX, AZ -- October 15, 2002 -- A clear pattern of laboratory findings has yet to be determined in nephrogenic fibrosing dermatopathology, but new research suggests a role for fibrogenic cytokines.
Lydon Dy Su, MD, a clinical assistant professor in the pathology department at University of Michigan Medical School, in Ann Arbor, Michigan, United States, reported the findings on 13 patients with nephrogenic fibrosing dermatopathology here last week at the annual meeting of the American Association of Dermatopathology (ASDP).
He stated that, "nephrogenic fibrosing dermatopathology (NFD) is a newly recognised cutaneous fibrosing disorder marked by the acute onset and persistence of woody induration involving the upper and lower limbs in patients with acute or chronic renal failure."
All 13 patients had developed renal failure before the disease began. Eight were on chronic haemodialysis, and two were on chronic peritoneal dialysis. Most patients had serious underlying diseases, and many were taking erythropoetin and/or cyclosporine therapy before disease onset.
No laboratory findings were consistently linked to the condition, according to the researchers. However, skin biopsies did reveal the presence of microfibroblasts, which indicates a potential role for fibrogenic cytokines in this disease.
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