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H. Pylori Lessens Activity Of Class IV Alcohol Dehydrogenate In The Stomach Of Gastric Ulcer Patients

A significant decrease occurs in the activity of class IV alcohol dehydrogenate (ADH) in the stomach of people infected with Helicobacter pylori, according to Polish researchers.

Various ADH isoenzymes are present in human stomachs and are known to be affected by a number of factors including H. Pylori.

In this study the activity of class I, III and IV DH isoenzymes in 68 patients with suspected gastric ulcers was investigated by Dr. L. Chrosteka and colleagues at the departments of Biochemical Diagnostics and Gastroenterology, Medical Academy Biaystok, Poland.

Endoscopic specimens of gastric mucous were taken from the corpus and Antrim parts of the stomachs of 42 men and 26 women.

Twenty-two samples from men and 13 from women were found to have H. Pylori colonisation.

The fluorimetric method with a specific substrate, 4-methoxy-1-naphthaldehyde, was used to measure the activity of class I isoenzyme. Class III activity was measured by the photometrical method with n-octanol and class IV activity was measured by m-nitrobenzaldehyde as substrates.

Compared with non-infected specimens, the activity of class IV isoenzyme was decreased in infected samples from the Antrim and corpus in the stomachs of both men and women.

In the infected specimens from the corpus of male subjects, the activity of class III isoenzyme was found to decrease.

No significant difference was seen, however, in the activity of class I between infected and non-infected samples from both sexes.
Digestion 2002;66:14-18. "Effect of Helicobacter pylori Infection on the Activity of Class I, III and IV Alcohol Dehydrogenase in the Human Stomach"

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