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H. Pylori/Ulcer
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my personal edition > h. pylori/ulcer > news
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DGReview
Vitamins C And E Do Not Aid In Helicobacter Pylori Eradication
A DGReview of :"Vitamin C and E Supplements to Lansoprazole-Amoxicillin-Metronidazole Triple Therapy May Reduce the Eradication Rate of Metronidazole-Susceptible Helicobacter pylori Infection."
Helicobacter
11/07/2002
By David Ball
Vitamins C and E, added to triple therapy, do not improve Helicobacter Pylori eradication rates, nor do they improve gastric inflammation.
In fact, addition of the vitamins may reduce eradication rate of triple therapy in patients with metronidazole susceptible strain infection.
In this study, investigators at the Department of Internal Medicine, Pathology, and Medical Technology, National Cheng Kung University, Tainan, Taiwan, randomised 104 H. pylori-infected patients into two groups.
A triple-only group received lansoprazole, amoxicillin and metronidazole twice daily for one week. The second group was given triple therapy twice daily along with vitamin C (250 mg) and vitamin E (200 mg) for one week and followed by vitamin C and E once daily for six consecutive weeks.
Subjects were assessed for the effectiveness of H. Pylori eradication eight weeks after the completion of triple therapy. Acute and chronic inflammation scores were assessed by the severity of gastric inflammation in histology.
In the triple-only group, intention-to-treat and per-protocol eradication rates were found to be 59.1 and 64.4 percent, whereas in the triple-plus-vitamin group they were 40 and 44 percent.
Subjects infected with metronidazole susceptible isolates were seen in the triple-only group to have a higher intention-to-treat eradication rate, 80 percent, compared with those in the triple-plus-vitamin group, 53.1 percent, (p <.01).
There was no difference, however, between the two groups in the intention-to-treat eradication rates for the metronidazole resistance isolates, 26.3 percent compared with. 21.7 percent.
No difference was seen either between the groups in improvements of both acute and chronic inflammation scores in histology.
Helicobacter 2002 Oct;7(5):310-6.
"Vitamin C and E Supplements to Lansoprazole-Amoxicillin-Metronidazole Triple Therapy May Reduce the Eradication Rate of Metronidazole-Susceptible Helicobacter pylori Infection."
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