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Relative Role of Endocrine Alterations and Malnutrition in Risk for Osteoporosis in Anorexia Nervosa
A DGReview of :"Osteoporosis and anorexia nervosa: relative role of endocrine alterations and malnutrition."
Eating and Weight Disorders
12/10/2002
By Mark Moran
Nutritional factors such as lean body mass and body mass index appear to be most important in assessing risk for osteoporosis among patients with anorexia nervosa, while endocrinological factors appear to be of limited importance.
Italian researches enrolled 49 young females with anorexia nervosa and malnutrition and 24 age-matched normal controls in whom the condition had been excluded on the basis of a clinical evaluation using DSM IV criteria. They studied bone density in early osteopenia, a condition in which the potential risk of fractures is high and traditionally related to a variety of endocrinological and nutritional factors.
Bone density was significantly lower in the patients with anorexia nervosa than the control group in all of the examined bone districts: bone mineral density (BMD) spine (p<0.0001), BMD neck (p<0.001), and BMD Ward (p<0.0001).
Body mass index (BMI) correlated with bone density, but caloric and calcium intake were not significant predictors. IGF-1, a known nutritionally dependent trophic bone factor, was significantly reduced in patients with anorexia nervosa but did not correlate with BMD. As in previous studies, there was a close correlation between lean body mass and BMD in neck and spine.
Physical exercise, urinary free cortisol osteocalcin and type I collagen-telopeptide (NTX) did not significantly correlate with the degree of osteopenia.
Eat Weight Disord 2002; Sep;7(3):190-5.
"Osteoporosis and anorexia nervosa: relative role of endocrine alterations and malnutrition."
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