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Lamotrigine Treats Depression in Patients with Epilepsy
A DGReview of :"Improvement in depression associated with partial epilepsy in patients treated with lamotrigine"
Epilepsy & Behavior
01/03/2003
By Alison Palkhivala
Lamotrigine may effectively treat symptoms of depression in epileptic patients with concomitant mood disorders, according to a small study.
In a study led by Dalma Kalogjera-Sackellares from the Malcolm Randall VA Medical Center and University of Florida in Gainesville, 13 adults with uncontrolled partial seizures and concomitant depression took lamotrigine for three months.
Participants in the study were evaluated for depression using the Montgomery and Asberg Depression Rating Scale (MADRS) and the Minnesota Multiphasic Personality Inventory (MMPI) Depression Scale. They were evaluated for anxiety using Spielberger's State-Trait Anxiety Inventory (STAI).
After five weeks on lamotrigine therapy, mean MADRS overall scores had significantly improved compared with baseline. This improvement was sustained after three months. MMPI depression scores were also significantly improved at three months. State anxiety scores were significantly improved at five weeks but not at three months, but trait anxiety scores were improved at both time points.
According these findings, lamotrigine may be a good option for epileptic patients with concomitant mood disorders, the authors write.
Epilepsy & Behavior 2002;3:6:510-516.
"Improvement in depression associated with partial epilepsy in patients treated with lamotrigine"
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