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Reduced Blood Pressure Correlated With Leptin After Weight Loss In Hypertensive Patients
A DGReview of :"Relationship between changes in serum leptin levels and blood pressure after weight loss."
Hypertension Research
01/06/2003
By James Adams
Reduced blood pressure is positively correlated with changes in serum leptin levels following weight loss in hypertensive patients but not in normal controls.
These results suggest that leptin is involved in the pathophysiology of obese hypertension, according to investigators from the Faculty of Nutritional Sciences at Nakamura Gakuen University in Fukuoka, Japan.
The investigators studied 31 hypertensive and 71 normotensive, moderately obese women during a three-month period of weight loss.
Age, fat-mass, homeostasis model assessment, summation of insulin, plasma renin activity and 24-hour norepinephrine excretion were all similar between the two groups of women before weight loss. Plasma leptin, however, was significantly higher in the hypertensive group after adjusting for abdominal fat.
Total abdominal fat, serum leptin and the summation of insulin decreased significantly in both groups following the three-month weight loss program.
A significant decrease in blood pressure was seen only in the hypertensive group, in which blood pressure changed from 144/84 to 130/77 mmHg after weight loss.
Decreases in plasma renin activity were observed in both groups. Only the hypertensive group showed a significant decrease in 24-hour norepinephrine excretion.
Serum leptin levels were positively correlated with both the homeostasis model assessment and the summation of insulin after weight loss in both groups.
Mean blood pressure was independently associated with 24-hour norepinephrine excretion and either the summation of insulin or the homeostasis model assessment in all subjects.
However, mean blood pressure was significantly correlated with leptin level only in the hypertensive group, after adjusting for total abdominal fat, 24-hour norepinephrine excretion and either the summation of insulin or the homeostasis model assessment.
Hypertens Res 2002; 25(6): 881-886.
"Relationship between changes in serum leptin levels and blood pressure after weight loss."
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