Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Hypertension
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Hypertension
    TopAbstracts in Hypertension 07/01/2009 - (DGNews)
    Certain Biomarkers Have Limitations in Predicting Cardiovascular Events - (DGNews)
    Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study - (BMJ)
    TopAbstracts in Hypertension 06/24/2009 - (DGNews)
    TopAbstracts in Hypertension 06/17/2009 - (DGNews)

    News archive

     Recent webcasts/CME - Hypertension
    Thrombotic Thrombocytopenic Purpura: The Masquerader
    Innovative Strategies in Cardiometabolic Risk Reduction
    Diuretics for the Treatment of Hypertension
    Managing Hypertension: Addressing the Challenges in Special Populations

    Webcasts/CME archive

     Recent cases - Hypertension
      Medical Management of a Pregnancy Woman with Moderate Renal Insufficiency and Superimposed Preclampsia
      Malignant Hypertension and Acute Aortic Dissection Associated with Caffeine-Based Ephedra-Free Dietary Supplements: A Case Report
      Giant Right Coronary Artery Aneurysm: Case Report and Literature Review
      Normalization of Systemic Arterial Hypertension Following Removal of Posterior Fossa Hemangioblastoma: A Case Report
      Headache and Seizure on Postpartum Day 5: Late Postpartum Eclampsia

      Cases archive
        




      my personal edition > hypertension > news
      divider

        E-Mail this DGReview to a colleague

      DGReview


      Amlodipine's Antihypertensive Effect Persists Longer Than Nifedipine Gastrointestinal Therapeutic System After Missed Doses

      A DGReview of :"Persistence of the antihypertensive efficacy of amlodipine and nifedipine GITS after two 'missed doses': a randomised, double-blind comparative trial in Asian patients."
      Journal of Human Hypertension

      02/03/2003
      By James Adams


      Amlodipine provides more persistent blood pressure control than does nifedipine gastrointestinal therapeutic system (GITS) following missed doses.

      Missed doses of antihypertensive medication are often the cause of suboptimal management of hypertension, explain investigators from St. Luke's Medical Centre in Quezon City in the Philippines. They conducted a multi-centre, randomized, double-blind, parallel-group study comparing the persistence of amlodipine and nifedipine GITS after two missed doses in 222 Asian patients with mild to moderate hypertension.

      Patients received either 5 milligrams of amlodipine or 30 milligrams nifedipine GITS daily for six weeks. Doses of each medication were doubled after six weeks if necessary for blood pressure control. Treatment continued for 12 weeks.

      Mean 24-hour ambulatory blood pressure levels were similar in both groups on the last day of treatment.

      After the 12-week treatment period, placebo was substituted for both medications for two days, and the effect on ambulatory blood pressure was monitored.

      Results showed significant differences in mean ambulatory blood pressure between the amlodipine and nifedipine GITS groups on the first day of treatment withdrawal.

      Increases in mean ambulatory blood pressure during the last nine hours of the second day of placebo administration were significantly lower in the amlodipine group.
      J Hum Hypertens 2002;16:11:805-813. "Persistence of the antihypertensive efficacy of amlodipine and nifedipine GITS after two 'missed doses': a randomised, double-blind comparative trial in Asian patients."

      E-Mail this DGReview to a colleague   To print, use this version






      All contents Copyright (c) 1995-2009 Doctor's Guide Publishing Limited. All rights reserved.



      The NTK initiative. Physicians helping physicians identify Need-To-Know science
         Feedback
      Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
      Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
      1
      2
      3
      4
      5
      6
      7
      Send