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Proximal Stomach Impaired In Alcohol-Related Liver Cirrhosis
A DGReview of :"Impaired accommodation of proximal stomach in patients with alcoholic liver cirrhosis."
Scandinavian Journal of Gastroenterology
01/21/2003
By James Adams
Patients with alcohol-related liver cirrhosis show impaired accommodation of the proximal stomach.
Previous studies have investigated the distal stomach and shown impaired gastric emptying in cirrhotic patients based on meal type.
Researchers from the 1st Department of Internal Medicine of the Faculty of Medicine at the University of Szeged, Hungary, investigated the effect of three different meal types on the proximal stomach in 21 cirrhotic patients and 15 healthy controls. Patients were divided into autonomic neuropathy positive and negative groups.
Subjects were given a liquid, low calorie meal; a semi-solid, low calorie meal; and a semisolid, high calorie and fat meal. Ultrasonography in a sagittal area and a frontal diameter was used to assess proximal gastric size in all the subjects.
Results showed that postcibal gastric size was significantly lower in the cirrhotic patients than in the controls immediately after ingestion of the liquid diet.
Proximal gastric size in the cirrhotic patients was also significantly lower than the healthy controls immediately after the ingestion of the semisolid, low calorie and low fat meal and remained lower at 10, 20 and 30 minutes after ingestion.
There was no difference between patients and controls after ingestion of the high calorie and high fat meal.
A difference between autonomic neuropathy positive and negative patients was observed only with the liquid diet. Patients with autonomic neuropathy showed significantly lower proximal gastric size following this meal compared with their autonomic neuropathy negative counterparts.
The proximal stomach appears to be impaired in alcohol-related liver cirrhosis, the investigators conclude.
Scand J Gastroenterol 2002; 37(12): 1403-1410.
"Impaired accommodation of proximal stomach in patients with alcoholic liver cirrhosis."
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