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H. Pylori/Ulcer
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my personal edition > h. pylori/ulcer > news
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DGReview
Low Levels of Serum Vitamin B May Be Related to Helicobacter Pylori Infection
A DGReview of :"An Association Between Helicobacter pylori Infection and Serum Vitamin B12 Levels in Healthy Adults."
Journal of Clinical Gastroenterology
02/14/2003
By David Ball
Helicobacter pylori infection may be associated with low vitamin B levels in healthy adults, say Israeli researchers.
A causal relationship between the "higher prevalence of infection among subjects with serum vitamin B levels that are within the lower end of the normal range" is suggested by investigators at the Hadasseh Hebrew University Hospital Jerusalem, Israel.
In this study of 133 adults, the researchers examined whether serological evidence of infection correlated with serum vitamin B levels in non-vitamin B deficient healthy adults.
All the subjects, who presented to a community based primary care clinic, were checked against exclusion criteria such as history of eradication or antacid use, liver disease and inflammatory bowel disease. Exclusion criteria included previous gastrointestinal surgery, a vegetarian diet or multivitamin supplementation.
Blood samples were taken for a complete blood count, serum vitamin B, gastrin, folic acid and IgG antibodies. Patients in the deficient range, vitamin B </= 145 ng/mL, were excluded.
Ninety-six of the subject group, 72.2%, were found to be seropositive for IgG antibodies (HP+). There was no difference between the age of HP(+) subjects and that of seronegative subjects (HP-); 52.8 ± 1.6 mean ± SE versus 49.2 ± 2.9 ( = NS).
A significantly higher prevalence of HP seropositivity was seen among subjects with borderline (>145-180 pg/mL) or low normal (>180-250 pg/mL) vitamin B levels compared with those with vitamin B >250 pg/mL.
Of 25 subjects with vitamin B >145-180 pg/mL, 92% were seropositive.
Eighty-nine percent of the 47 subjects with vitamin B greater than 180-250 pg/mL were found to be seropositive compared with 51%, 31 out of 61, of subjects with B less than 250 pg/mL, Fisher exact test < 0.0001.
No correlation was seen between vitamin B levels and age (r = -0.07).
There was no significant difference in gastrin levels (pg/mL) between groups; 70.2 ± 5.8 in HP(+) versus 56.0 ± 12.4 in HP(-).
J Clin Gastroenterol 2003 Feb;36:2:130-3.
"An Association Between Helicobacter pylori Infection and Serum Vitamin B12 Levels in Healthy Adults."
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