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Antipsychotic Use A Risk Factor For Endometrial Cancer

Use of antipsychotics is a risk factor for endometrial cancer in pre-menopausal women, Japanese researchers report.

Antipsychotics are also a common cause of hyperprolactinemia, say investigators from the Graduate School of Medicine at Chiba University in Chiba. They go on to explain that most endometrial cancers are related to hormonal imbalance.

Diabetes mellitus and obesity were also identified as independent variables for endometrial cancer in a study of 41 patients with histologically confirmed disease and controls matched on a 3 to 1 basis by age and date of hospital visit.

The researchers examined the relationship between antipsychotic use and endometrial cancer risk in a case-controlled study of pre-menopausal women reporting to Chiba University Hospital between 1989 and 2000. The endometrial cancer patients were matched with 123 women without endometrial cancer enrolled as controls.

Data on obesity, parity, hypertension, diabetes mellitus, use of exogenous oestrogen and antipsychotic use were analysed. Conditional logistic regression analysis was used to estimate odds ratios, two-sided p values and 95% confidence intervals.

Five endometrial cancer patients used antipsychotics. In four of these patients, radioimmunoassay was used to measure serum luteinising hormone, follicle-stimulating hormone, prolactin, estradiol and progesterone.

Risk estimates were identified for use of antipsychotics (5.4), diabetes mellitus (9.3) and obesity (4.9).
Oncology, 2003;64:2:116-123. "A Case-Control Study of Endometrial Cancer after Antipsychotics Exposure in Premenopausal Women"

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