Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Surgery
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Surgery
    Lymph Node Stage and Adjuvant Chemotherapy Are Prognostic Factors for Survival in Patients With Advanced Bladder Cancer: Presented at EMUC - (DGDispatch)
    Research Sheds New Light on Epilepsy - (DGNews)
    Adjuvant Radiotherapy After Radical Prostatectomy Provides Progression-Free Survival Benefits Independent of Margin Length: Presented at EMUC - (DGDispatch)
    Adding Cetuximab to Chemotherapy Increases Tumour Shrinkage In Advanced Colorectal Cancer - (DGNews)
    No Significant Benefits to Adding Clopidogrel to Aspirin After Coronary Bypass Surgery: Presented at AHA - (DGDispatch)

    News archive

     Recent webcasts/CME - Surgery
      PreAnesthetic Assessment of the Patient for Lung Resection
      Arteriovenous Malformations Dural Arteriovenous Shunts
      Aneurysm Rupture and Subarachnoid Hemorrhage Cerebral Revascularization: The Role of EC-IC Bypass in the 21st Century
      Vitamin Deficiency After Gastric Bypass Surgery: A Review
      Advances in Surgical Treatments for Crohn's Disease

      Webcasts/CME archive

       Recent cases - Surgery
        Frontal Skull Craniotomy Combined With Moderate-Dose Radiotherapy Effectively Ameliorate A Rare Case Of Non-Secretory, Multiple Myeloma With Orbital Involvement
        Proximal Tibiofibular Dislocation Associated With Fracture Of The Tibia: A Case Report
        Munchausen Syndrome In The Emergency Department Mostly Difficult, Sometimes Easy To Diagnose: A Case Report And Review Of The Literature
        Pigmented Villonodular Synovitis of the Knee in a Patient on Oral Anticoagulation Therapy: A Case Report
        Jejuno-Jejunal Invagination Caused by Epithelioid Sarcoma: A Case Report

        Cases archive
          




        my personal edition > surgery > news
        divider

          E-Mail this DGReview to a colleague

        DGReview


        Anti-p53 Antibodies And C-Reactive Protein Are Prognostic Factors In Recurrent Oesophageal Cancer

        A DGReview of :"Treatment response and prognosis of patients after recurrence of esophageal cancer."
        Surgery

        02/07/2003
        By James Adams


        Serum concentrations of anti-p53 antibodies and C-reactive protein appear to be independent prognostic factors in patients with recurrent oesophageal cancer.

        Investigators, from the Department of Academic Surgery and Radiology at Chiba University Graduate School of Medicine in Chiba, Japan, studied 258 patients who underwent radical oesophagectomy with extended lymphadenectomy for oesophageal squamous cell carcinoma between 1990 and 1999.

        Operative specimens were analyzed and depth of tumour invasion and lymph node metastases were also evaluated.

        To monitor recurrence, tumour markers were assessed every three months, ultrasound examinations were performed every six months and computed tomography was performed annually. Mean follow-up after surgery was 22 months.

        Ninety-five out of 258 patients experienced recurrence. Seventy-six of these patients received non-surgical treatment and seven underwent operative intervention. The remaining twelve received no treatment.

        Clinicopathologic features of the recurrent tumours were analyzed, and concentrations of serum anti-p53 antibody, serum C-reactive protein and albumin were determined.

        Thirty-four percent of the patients who were treated non-surgically responded to treatment.
        Response was associated with type of recurrence, history of perioperative adjuvant therapy, time of recurrence, number of recurrent tumours, albumin concentration, serum anti-p53 antibody concentration and serum C-reactive protein concentration.

        Multivariate analysis revealed that serum anti-p53 antibody concentration and serum C-reactive protein concentration independently predicted treatment response.
        Surgery 2003;133:1:24-31. "Treatment response and prognosis of patients after recurrence of esophageal cancer."

        E-Mail this DGReview to a colleague   To print, use this version






        All contents Copyright (c) 1995-2009 Doctor's Guide Publishing Limited. All rights reserved.



        The NTK initiative. Physicians helping physicians identify Need-To-Know science
           Feedback
        Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
        Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
        1
        2
        3
        4
        5
        6
        7
        Send