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Vitamin C Reduces Oxidant Stress In Renal Failure
A DGReview of :"Vitamin C improves resistance but not conduit artery endothelial function in patients with chronic renal failure"
Kidney International
03/26/2003
By Robert Short
The acute administration of vitamin C reduces oxidant stress in renal failure, and improves nitric oxide-mediated resistance-vessel dilatation.
These were the findings of a study of 33 pre-dialysis and 17 haemodialysis patients, investigating the effect of vitamin C on endothelium-dependant responses in both the conduit and resistance vasculature in severe renal impairment.
Pre-dialysis patients received vitamin C by intra-arterial infusion (25 mg/min) and haemodialysis patients received intravenous infusion (3g).
The parenteral administration of vitamin C resulted in a 100-fold increase (intra-arterial studies) and a 4.5 fold increase (intravenous studies) in serum antioxidant activity. In addition, vitamin C was found to increase the dilator response to acetylcholine in resistance vessels, but did not alter the dilator response to flow in conduit vessels of either dialysis or pre-dialysis subjects.
The investigators reported that there was not, in the presence of the nitric oxide synthase inhibitor NGmonomethyl-1-argine (L-NMMA), any effect of vitamin C on resistance vessel endothelial function. Vitamin C did not appear to have any affect on the dilator response to the endothelium-independent dilators.
Kidney Int 2003;63:4:1433-1442.
"Vitamin C improves resistance but not conduit artery endothelial function in patients with chronic renal failure"
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