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        Tretinoin Emollient Cream Safe And Effective for Long-Term Treatment of Wrinkles and Hyperpigmentation: Presented at AAD

        By Alison Palkhivala

        SAN FRANCISCO, CA -- March 26, 2003 -- Long-term use of 0.05% tretinoin emollient cream safely improves the problems associated with photodamaged skin, such as wrinkling and mottled hyperpigmentation, according to a multicentre study.

        Lead researcher Sewong Kang, MD, from the department of dermatology, University of Michigan, Ann Arbor, United States, presented the findings here on March 22nd at the 61st Annual Meeting of the American Academy of Dermatology.

        The study included 204 patients aged 30 to 75 with lightly pigmented and/or moderate to severe photodamaged skin, who were randomised to treatment with a 0.05% tretinoin emollient cream or a vehicle alone (placebo).

        Among the 160 patients who completed the 24-month treatment period, those using the tretinoin cream had significantly better improvements than those who used the placebo with respect to fine wrinkling and mottled hyperpigmentation (p=0.002 for both). There was no difference between the two groups with respect to tactile roughness.

        In terms of secondary end points, the tretinoin cream was also significantly superior to placebo with respect to improving coarse wrinkling (p=0.029), sallowness (p=0.008) and lentigines (p=0.006). Physicians' global assessment was also superior for patients using the tretinoin cream rather than the placebo (p=0.002).

        The most common adverse event associated with use of the tretinoin cream was mild cutaneous irritation, which peaked at 2 months.

        Based on these findings, the authors concluded that a tretinoin 0.05% cream offers long-term safety and efficacy for the treatment of fine wrinkles, mottled hyperpigmentation, coarse wrinkles, sallowness and lentigines in patients with moderate to severe photodamaged skin.

        Ortho Neutrogena sponsored the study.


        [Study title: Safety and Efficacy of Long-Term Use of Tretinoin Emolient Cream 0.05% for the Treatment of Photodamaged Facial Skin: Review of a Clinical Trial. Abstract p100]



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