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Orlistat Plus Low Calorie Diet Enhances Weight Loss
A DGReview of :"Effect of orlistat added to diet (30% of calories from fat) on plasma lipids, glucose, and insulin in obese patients with hypercholesterolemia"
American Journal of Cardiology
04/23/2003
By David Loshak
Hypercholesterolaemic patients who are treated with orlistat, a lipase inhibitor, lose significantly more weight than do those on a reduced calorie diet only.
A further finding, reported by researchers at Hoffman-La Roche Inc., Nutley, New Jersey, indicated that the patients receiving orlistat also showed significantly greater reductions in plasma cholesterol, low density lipoprotein, triglycerides, glucose and insulin than did diet-only patients.
The study was carried out to quantify the effectiveness of the drug plus a reduced calorie diet on reducing the risk of cardiovascular disease in obese people with elevated low density lipoprotein levels. The researchers also compared the beneficial effects in patients who had hypercholesterolaemia only (type IIA) with those in patients who had combined dyslipidaemia (type IIB).
Weight loss of orlistat recipients was independent of the form of dyslipidaemia, it was found. Plasma total and low density lipoprotein and insulin levels fell significantly more in patients who received orlistat and who had either type IIA and IIB dyslipidaemia.
On the other hand, triglyceride and insulin concentrations fell and high density lipoprotein rose significantly more after orlistat-assisted weight loss in patients with type IIB than with type IIA, which was associated with a significantly greater fall in the ratio of low density to high density lipoprotein.
The researchers concluded that weight loss in response to a reduced calorie diet in obese hypercholesterolaemic patients was associated with a significant fall in plasma low density lipoprotein cholesterol levels.
The beneficial metabolic effects of weight loss were accentuated in response to orlistat; patients who had combined dyslipidaemia improved the most.
American Journal of Cardiology 2003;91:8:961-964.
"Effect of orlistat added to diet (30% of calories from fat) on plasma lipids, glucose, and insulin in obese patients with hypercholesterolemia"
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