Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Pregnancy
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Pregnancy
    CDC Study Shows Assisted Reproductive Technology May Increase Risk of Certain Birth Defects - (DGNews)
    Pregnancy and Fertility Following Bariatric Surgery: A Systematic Review - (JAMA)
    TopAbstracts in Pregnancy 11/18/2008 - (DGNews)
    Study Finds Possible Link Between Diabetes, Pelvic Girdle Syndrome - (DGNews)
    Timing of Oocyte Retrieval Can Determine Outcome of In Vitro Fertilisation: Presented at ASRM - (DGDispatch)

    News archive

     Recent webcasts/CME - Pregnancy
    • Some Anti-Epileptic Drugs May Compromise Bone Health
    • Balancing Treatment With Reproductive Health in Women With Epilepsy
    • Reducing Recurrent Preterm Birth: Appropriate Use of 17 Alpha Hydroxyprogesterone Caproate
      Fetal Alcohol Spectrum Disorders (FASD): What it as and How it Affects the Child, the Family and Society: FASD and its Effects II
      Fetal Alcohol Spectrum Disorders (FASD): What it is and How it Affects the Child, the Family and Society: FASD and its Effects I

      Webcasts/CME archive

       Recent cases - Pregnancy
        Postpartum Thunderclap Headache
        Sweet Syndrome During Pregnancy
        Bilateral Femoral Neck Fractures Due to Transient Osteoporosis of Pregnancy: A Case Report
        Complete Uterine Inversion During Caesarean Section: A Case Report
        Pneumothorax, Pneumomediastinum, Tracheo-Esophageal Fistula Presenting with Endotracheal Intubation in Post-Cesarean Period: A Case Report

        Cases archive
          




        my personal edition > pregnancy > news
        divider

          E-Mail this DGReview to a colleague

        DGReview


        Prenatal Use of Nonsteroidal Anti-inflammatory Drugs Significantly Increases Risk of Miscarriage

        British Medical Journal (BMJ)

        08/14/2003
        By Joene Hendry


        Women who use non-steroidal anti-inflammatory drugs (NSAIDs) during the prenatal months, especially around the time of conception or for more than 1 week, significantly increase their risk of miscarriage, according to a population based cohort study.

        While these findings need further confirmation, "it may be prudent for physicians and women who are planning to be pregnant to be aware of this potential risk and avoid using NSAIDs around conception," writes epidemiologist De-Kun Li and colleagues from Kaiser Foundation Research Institute, Oakland, California United States.

        The researchers analysed pregnancy outcomes up to 20 weeks gestation in 1,055 women enrolled in the Kaiser Permanente Medical Care Program in the San Francisco area of northern California. A total of 53 women (5%) reported prenatal NSAID use around the time of conception or during pregnancy.

        When results were adjusted for confounders, including previous miscarriage, maternal age, gravidity, use of a hot tub, multivitamin use, smoking since last menstruation, education, and race, prenatal NSAID use was associated with an 80% increased risk of miscarriage (hazard ratio [HR] 1.8).

        Among NSAID users, the HR for risk of miscarriage was 5.6 for use during conception and 1.2 for use after conception. The HR was 1.3 for those who used NSAIDs for less than 1 week, but was 8.1 for those who used NSAIDs for 1 week or longer. Further adjustments for alcohol or coffee drinking during the prenatal period did not change these results.

        The investigators noted a similar association between increased risk of miscarriage and prenatal aspirin use.

        Conversely, use of paracetamol during pregnancy was not associated with risk of miscarriage regardless of the timing or duration of use. Among 172 users of paracetamol, compared with 762 non-users, overall HR for the risk of miscarriage was 1.2.
        BMJ 2003;327:368-71.

        E-Mail this DGReview to a colleague   To print, use this version






        All contents Copyright (c) 1995-2008 Doctor's Guide Publishing Limited. All rights reserved.



        The NTK initiative. Physicians helping physicians identify Need-To-Know science
           Feedback
        Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
        Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
        1
        2
        3
        4
        5
        6
        7
        Send