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Glargine May Improve Glycemic Control in Children and Adolescents with Diabetes
A DGReview of :"Effect of therapy with insulin glargine (lantus) on glycemic control in toddlers, children, and adolescents with diabetes"
Diabetes Technology & Therapeutics
12/12/2003
By Mary Beth Nierengarten
Glargine therapy may decrease haemoglobin A1C (HbA1C) and frequency of hypoglycaemia without increasing bone mineral index or insulin requirements in toddlers, children, and adolescents with diabetes, reports a study from the United States.
In this retrospective study, EH Hathout, MD, and colleagues from Loma Linda University, California, evaluated the effect of insulin glargine on glycaemic control in 72 children and adolescents with type 1 or type 2 diabetes. Of the cohort, 60% were female and 83% had type 1 diabetes. At initiation of glargine treatment, the mean patient age was 12.5 years (range, 1.2 to 19.6 years), mean HbA1C was 9.7, and bone mineral index (BMI) was 22.48 kg/m2, and patients had had diabetes for a mean of 3.58 years with a mean baseline insulin dose of 0.93 U/kg a day.
Glycaemic control was assessed by use of a repeat-measure analysis of variance performed of HbA1C, frequency of hyperglycaemia and hypoglycaemia, body mass index (BMI), mean blood glucose, and daily weight-adjusted dose of insulin prior to and following administration of glargine therapy.
Regardless of type of diabetes, a significant decrease in HbA1C was found after administration of glargine therapy, with an average decrease of 9.5% prior to therapy to 8.6% after therapy (P < .001). No increase in the frequency of hypoglycaemia, weight-adjusted insulin dose, or BMI occurred as a result of this decrease. In patients with type 1 diabetes, hypoglycaemia also decreased.
These results suggest to the authors that glargine therapy may decrease HbA1C in children and adolescents without increasing insulin requirements or BMI, and may also be associated with a decrease in the frequency of hypoglycaemia.
Diabetes Technol Ther 2003;5:5:801-6.
"Effect of therapy with insulin glargine (lantus) on glycemic control in toddlers, children, and adolescents with diabetes"
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