Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Cardiology Other
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Cardiology Other
    Coronary Arterial Calcium Scans Help Detect Overall Death Risk in the Elderly - (DGNews)
    Angiotensin II blockade and aortic-root dilation in Marfan's syndrome - (N Engl J Med)
    EMEA Recommends Updated Label Warnings for Etoricoxib-Containing Drugs - (DGNews)
    Silent Cerebral Infarction Reported in 10% of Healthy People - (DGNews)
    New Guidance Available for Cardiologists Treating Myocardial Bridging - (DGNews)

    News archive

     Recent webcasts/CME - Cardiology Other
    • Improving Outcomes in Hypertension and Congestive Heart Failure: Focus on New Generation ß-Blockers
    • Antithrombin Therapies: Translating Clinical Trials into Practice
      Update on the Management of Acute Decompensated Heart Failure: Incorporating Treatment Guidelines and Recent Clinical Research Findings into Practice
      The Cardio-Renal Link: Preventing Cardiovascular Disease and Diabetes in Renal Transplant Recipients
      Primary Pulmonary Hypertension

      Webcasts/CME archive

       Recent cases - Cardiology Other
        Response of Pulmonary Artery Intimal Sarcoma to Surgery, Radiotherapy and Chemotherapy: A Case Report
        Pericardial Effusion as the Only Manifestation of Infection with Francisella tularensis: A Case Report
        Caseous Calcification of the Mitral Annulus with Mitral Regurgitation and Impairment of Functional Capacity: A Case Report
        Suspected Association of Ventricular Arrhythmia with Air Pollution in a Motorbike Rider: A Case Report
        Long-Term Event-Free Survival with an Embolised Prosthetic Valve Leaflet in the Thoracic Aorta

        Cases archive
          




        my personal edition > cardiology other > news
        divider

          E-Mail this DGDispatch to a colleague

        DGDispatch


        Leptin Level Predicts Outcome in Coronary Atherosclerosis: Presented at ACC

        By Jill Stein

        NEW ORLEANS, LA -- March 8, 2004 -- Leptin is a novel and powerful prognosticator of future cardiovascular events in patients with angiographically confirmed coronary atherosclerosis, researchers report. What's more, plasma leptin can predict cardiovascular events in these patients independent of other risk factors, including lipid status and C-reactive protein.

        Dr. Robert Wolk, with the Mayo Clinic in Rochester, Minnesota, presented the findings here March 7th at the 53rd Annual Scientific Session of the American College of Cardiology.

        Leptin is a novel bioactive hormone derived predominantly from the adipose tissue. Although originally viewed as a mediator involved mainly in energy homeostasis, several cardiovascular actions of leptin (such as sympathetic activation, pressor effects, regulation of vascular function, insulin resistance, oxidative stress, enhancement of platelet aggregation and impaired fibrinolysis) suggest that leptin may also play an important role in the development of cardiovascular disease, Dr. Wolk pointed out. The pathophysiological role and clinical predictive value of leptin in humans have not yet been established.

        In the study, subjects were recruited prospectively from a cohort of 382 patients undergoing clinically indicated coronary angiography.

        All patients were followed for the occurrence of cardiac death, new myocardial infarction, cerebrovascular accident, and revascularization, and the median duration of follow-up was 4 years. Follow-up information was available in 361 patients.

        During the follow-up, the endpoint was seen in 44 subjects (5 cardiac deaths, 12 myocardial infarctions, 12 percutaneous coronary interventions, 9 coronary artery bypass grafting operations, and 6 cerebrovascular accidents).

        The only two variables significantly associated with the endpoint in the multivariate analysis were leptin (P = .004) and the number of coronary vessels with >50% stenosis (P < .001). A similar relationship between leptin and prognosis was observed when leptin was adjusted for body mass index.

        Dr. Wolk said that the findings may have important implications for both clinical risk stratification and for understanding the pathophysiological mechanisms underlying cardiovascular morbidity and mortality.


        [Study title: Plasma Leptin Level is an Important and Independent Predictor of Prognosis in Patients With Established Coronary Atherosclerosis. Abstract 408-5]



        E-Mail this DGDispatch to a colleague   To print, use this version






        All contents Copyright (c) 1995-2008 Doctor's Guide Publishing Limited. All rights reserved.



        The NTK initiative. Physicians helping physicians identify Need-To-Know science
           Feedback
        Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
        Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
        1
        2
        3
        4
        5
        6
        7
        Send