Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Interventional Radiology
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Interventional Radiology
    Nearly Three-Quarters of Symptomatic Women Are Candidates for Focused Ultrasound Fibroid Therapy: Presented at RSNA - (DGDispatch)
    Kidney Cancer Cryoablation Results in 9% Recurrence Rate After at Least 5 Years of Follow-Up: Presented at RSNA - (DGDispatch)
    Extensive Fibroid Destruction With Focused Ultrasound Appears Safe: Presented at RSNA - (DGDispatch)
    Ultrasound-Guided Dry Needling Appears to Relieve Pain of Plantar Fasciitis: Presented at RSNA - (DGDispatch)
    New Method Estimates Radiation Skin Doses During CT-Guided Interventional Procedures - (DGNews)

    News archive

     Recent webcasts/CME - Interventional Radiology
    Long-Term Effects on Arterial Healing with DES

    Webcasts/CME archive

     Recent cases - Interventional Radiology
      Severe Bleeding from Esophageal Varices Resistant to Endoscopic Treatment in a Non Cirrhotic Patient with Portal Hypertension
      An Unusual Complication Following Radiological Percutaneous Gastrostomy
      Computerized Tomographic Angiography for Preoperative Assessment of the Superficial Temporal Artery for External Carotid Artery to Internal Carotid Artery Bypass: A Case Report
      Splenic Infarction Complicating Percutaneous Transluminal Coeliac Artery Stenting for Chronic Mesenteric Ischaemia: A Case Report
      Massive Hematuria Due to Congenital Renal Arteriovenous Malformation Mimicking a Renal Pelvis Tumor: A Case Report

      Cases archive
        




      my personal edition > interventional radiology > news
      divider

        E-Mail this DGDispatch to a colleague

      DGDispatch


      Low 1-Year Survival Observed With Radioactive Spheres in Advanced Hepatocellular Carcinoma: Presented at SIR

      By Ed Susman

      WASHINGTON, DC -- March 25, 2008 -- The use of radioactive beads for embolisation and radiation of hepatocellular carcinoma does not appear to appreciably extend survival in patients with advanced disease, researchers said here at the Society of Interventional Radiology (SIR) 33rd Annual Scientific Meeting.

      "While a response to selective internal radiation therapy can be seen in some patients with advanced hepatocellular carcinoma, overall survival is poor at 1 year," said Darryl A. Zuckerman, MD, Associate Professor of Clinical Radiology, University of Cincinnati, Cincinnati, Ohio.

      In his series of 30 patients treated with selective internal radiation therapy utilising Yttrium-90 microscopic radioactive glass beads, the 1-year survival was about 24% -- similar to the rate seen in other studies with a similar patient population.

      "The role of selective internal radiation therapy in these patients may be as part of a multimodality approach in which other therapies are considered in combination or as a bridge to liver transplantation in a small subset of patients," Dr. Zuckerman said in his poster presentation on March 18.

      "Ultimately a randomised, controlled trial may be required to determine the clinical value of using selective internal radiation therapy in stage III and stage IV patients," he said.

      In their study, Dr. Zuckerman and colleagues enrolled 30 consecutive patients with stage III or stage 4 disease who were expected to have 3 months or more of life, an Eastern Cooperative Oncology Group performance status less than 3, relatively good kidney function, and hepatic blood vessels that were able to handle selective catheterisation.

      Patients had a mean age of 61.5 years, but ranged from 20 to 86 years. Ten of the patients had disease progression after receiving prior interventions. Fourteen of the patients had infiltrative tumours; 11 had multicentric tumours and 5 had solitary masses.

      The beads delivered a mean of 118.5 Gy to the tumours. In most of the patients the procedure produced little response, although in tumours that showed some necrosis at baseline, use of selective internal radiation therapy did produce complete responses in 2 patients and partial responses in 15 patients.

      However, 1-month survival after treatment was 96.9%, 3-month survival was 77.5%, 6-month survival was 59.9%, 9-month survival was 43.5%, 1-year survival was 24.2%, and 18-month survival was 16.1%, Dr. Zuckerman reported.

      Five of the patients in the study developed grade 3/4 liver toxicity and 1 patient developed a gastric ulcer believed to be related to treatment. The ulcer was treated conservatively and resolved.


      [Presentation title: Effectiveness of Selected Internal Radiation Therapy in Advanced Hepatocellular Carcinoma: Single Center Experience. Abstract 361]



      E-Mail this DGDispatch to a colleague   To print, use this version






      All contents Copyright (c) 1995-2008 Doctor's Guide Publishing Limited. All rights reserved.



      The NTK initiative. Physicians helping physicians identify Need-To-Know science
         Feedback
      Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
      Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
      1
      2
      3
      4
      5
      6
      7
      Send