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Norfloxacin Offers Fewer Recurrences of Urinary Tract Infection in Diabetic Women Than Nitrofurantoin or Trimethoprim: Presented at ICAAC/IDSA
By Maggie Schwarz
WASHINGTON, DC -- October 30, 2008 -- Diabetic women generally had fewer recurrences of urinary tract infection when treated with norfloxacin compared to trimethoprim or nitrofurantoin, irrespective of treatment duration researchers announced here at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and Infectious Diseases Society of America (IDSA) 46th Annual Meeting.
A team of Dutch investigators set out to determine whether women with diabetes have lower urinary tract infection recurrence rates when treated with an antibiotic with high tissue penetration (norfloxacin) as compared with antibiotics with low tissue penetration (trimethoprim or nitrofurantoin), explained coinvestigator Ronald P. Stolk, MD, PhD, University Medical Centre Groningen, Groningen, The Netherlands.
The investigators obtained data from the PHARMO Institute, a Dutch national registration database with pharmacy dispensing data. Case reports from a total of 10,349 women with diabetes were included in the study. All subjects had received a first course of trimethoprim, nitrofurantoin, or norfloxacin between 1999 and 2005.
Urinary tract infection recurrence rates after treatment with norfloxacin were compared to those following trimethoprim or nitrofurantoin treatment within different treatment duration groups. Recurrence was defined as a second prescription for the above medications or a first prescription with amoxicillin (clavulanic acid), fluoroquinolones, or trimethoprim/sulfamethoxazole between 6 and 30 days after the first course of antibiotics.
Premenopausal women with diabetes had fewer recurrences when treated with norfloxacin versus trimethoprim or nitrofurantoin for at least 4 days.
Postmenopausal women with diabetes had fewer recurrences when treated with norfloxacin versus trimethoprim or nitrofurantoin.
[Presentation title: Treatment of Urinary Tract Infections (UTI) in Women With Diabetes Mellitus (DM); Lower Recurrence Rate With Norfloxacin Compared to Nitrofurantoin or Trimethoprim. Abstract L-613]
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