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DGAbstract

Trichilemmal carcinoma with neuroendocrine differentiation

Clinical and Experimental Dermatology

12/17/2007

We report a 12-mm nodular, cream-coloured skin lesion that appeared on the left nasal ala in an 81-year-old man. This trabecular infiltrative tumour showed keratin microcysts, stromal hyalization, cytoarchitectural malignancy features, colonizing melanocytes, and immunoexpression of epithelial membrane antigen, cytokeratin 15/20, chromogranin, synaptophysin and CD56. To our knowledge, this is the first documented case of a trichilemmal carcinoma with neuroendocrine differentiation and melanocyte colonization, which is suggested by the trabecular growth pattern and requires immunohistochemical confirmation.

Clin Exp Dermatol. 2007 Dec 10 [Epub ahead of print]

"Trichilemmal carcinoma with neuroendocrine differentiation"

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