Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Thrombosis
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Thrombosis
    Study Challenges Association Between Pulmonary Embolism and DVT - (DGNews)
    Postoperative Thrombin Generation in Cardiac Surgery: Presented at ASA - (DGDispatch)
    Postoperative Anticoagulation Therapy Necessary in Patients Following Major Surgery: Presented at ASA - (DGDispatch)
    Progestin Use, But Not Oestrogen Use, Associated With Higher Risk of Venous Thromboembolic Events: Presented at NAMS - (DGDispatch)
    Lupus Anticoagulant Increases Risk of Stroke, MI In Young Women - (DGNews)

    News archive

     Recent webcasts/CME - Thrombosis
    • Managing Treatment- and Disease-Related Complications in Multiple Myeloma
    • Thrombosis in Multiple Myeloma: Choice of Thromboprophylaxis Depends on Type of Therapy and Individual Risk of Patient
    • Peripheral Neuropathy in Multiple Myeloma: Early Recognition and Intervention Key to Minimize Long-Term Complications
    • Myeloma Bone Disease: Is Targeting of Osteoclastic and Osteoblastic Mechanisms Necessary for Effective Therapy?
    • Update on DVT and PE in OB Gyn/Ortho Patients

      Webcasts/CME archive

       Recent cases - Thrombosis
        Multiorgan Paradoxical Embolism Consequent to Acute Pulmonary Thromboembolism with Patent Foramen Ovale: A Case Report
        Thrombotic Thrombocytopenic Purpura Complicated with Hypereosinophilic Syndrome
        Assessment of Specific Risks for the Recurrence of Deep Vein Thrombosis: A Case Report
        Pancreatic Carcinoma Associated with Portal Vein Tumor Thrombus: Three Case Reports
        Pulmonary Embolism Due to Internal Jugular Vein Thrombosis without an Indwelling Catheter

        Cases archive
          




        my personal edition > thrombosis > news
        divider

          E-Mail this DGReview to a colleague

        DGReview


        Rapid D-Dimer Methods Comparable To ELISA For Detecting Deep Vein Thrombosis

        Blood Coagulation and Fibrinolysis

        09/19/2003
        By Emma Hitt, PhD


        Rapid D-dimers assays appear to be highly sensitive for detecting deep vein thrombosis (DVT), according to new research.

        Enzyme-linked immunosorbent assay (ELISA), currently the gold standard for detecting DVT, requires specialised equipment, technical expertise, and 2 to 3 hours to perform. In contrast, newer methods for measuring D-dimers, based on ELISA and immunoturbidometry, allow diagnosis in less than 1 hour, and require only limited technical expertise.

        To compare these newer methods with ELISA, Robert C. Gosselin, MD, with the University of California Davis Medical Center, Sacramento, United States, and colleagues evaluated 151 patients suspected of DVT.

        A whole blood D-dimer test (SimpliRED, Agen) was performed, and then tested using enzyme-linked immunosorbent assay (VIDAS D-Dimer, BioMerieux; Asserachrome D-Di, Stago International; Dimertest Gold, Agen) and automated immunoturbidometric methods (Advanced D-Dimer, Dade Behring; MiniQuant, Biopool). The researchers then compared each D-dimer method with radiographic results to determine sensitivity and negative predictive value (NPV).

        Of the patients, 23.2% had a positive Doppler ultrasound, with 26 proximal, 8 distal thromboses. One patient had both proximal and distal thromboses. Two patients were excluded due to inconclusive results.

        Overall, the sensitivities for the rapid D-dimer methods were: SimpliRED, 82.3%; VIDAS D-Dimer, 91.4%; MiniQuant D-Dimer, 96.3%; and Advanced D-Dimer, 97.1%.

        In the inpatient only population, the sensitivity was increased: SimpliRED (86.4%), VIDAS D-Dimer (95.5%), MiniQuant D-Dimer (100%), and Advanced D-Dimer (100%).

        "The VIDAS D-Dimer, MiniQuant D-Dimer, and Advanced D-Dimer all demonstrate high sensitivity and NPV in patients suspected of DVT," the researchers conclude. "All D-dimer methods compared favourably with the more traditional ELISA methods, yet have the advantage of being quicker and easier to run," they add.

        According to the researchers, these D-dimer methods could be safely substituted for ELISA tests as part of the DVT work-up. However, the SimpliRED whole-blood method was only moderately sensitive and "therefore must be used in conjunction with probability estimates and other radiographic studies to be of clinical value," they note.

        "Further clinical management studies are necessary to determine the thrombotic risk in patients with negative Advanced D-dimer and Mini-Quant D-dimer results to assure that these tests can safely exclude DVT in symptomatic patients," they suggest.


        Blood Coagul Fibrinolysis 2003;14:545-550.

        E-Mail this DGReview to a colleague   To print, use this version






        All contents Copyright (c) 1995-2009 Doctor's Guide Publishing Limited. All rights reserved.



        The NTK initiative. Physicians helping physicians identify Need-To-Know science
           Feedback
        Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
        Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
        1
        2
        3
        4
        5
        6
        7
        Send