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DGAbstract
Identification of a Genetic Locus for Ichthyosis Vulgaris on Chromosome 10q22.3-q24.2
Journal of Investigative Dermatology
12/18/2007
Ichthyosis vulgaris (IV) is one of the most commonly inherited disorders and has an estimated prevalence rate of 2.29% in China. To date, only one gene responsible for IV, the filaggrin gene (FLG), was identified, but genetic heterogeneity exists. In this study, two Chinese families with autosomal-dominant IV were genetically characterized. The FLG gene was first excluded as the disease-causing gene in the two families. The larger family was then characterized by genome-wide linkage analysis to identify a new genetic locus for IV.
J Invest Dermatol. 2007 Dec 13 [Epub ahead of print]
"Identification of a Genetic Locus for Ichthyosis Vulgaris on Chromosome 10q22.3-q24.2"
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