Source: DGNews | Posted 9 years ago
Temozolomide Improves Response of Brain Metastases to Radiation Therapy
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By Emma Hitt
Special to DG News
NEW ORLEANS, LA -- October 9, 2002 -- In patients with brain metastases undergoing whole brain radiation therapy, use of the oral alkylating agent temozolomide significantly increases the response rate, according to findings of a phase III trial.
Dr. Desonie Antonadou, with the Metaxas Cancer Hospital, in Pireus, Greece presented the findings here October 8 at the 44th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO).
Temozolomide is similar to other oral alkylating agents, but it crosses the blood brain barrier, According to Dr. Antonadou. She also pointed out that it is convenient to use and can be given on an outpatient basis.
Her study enrolled 134 patients with brain metastases, 82 percent of them with primary lung cancer. Patients were randomised to receive whole brain radiation 30Gy given in 10 fractions with or without temozolomide 75 mg/m
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