Source: DGNews | Posted 9 years ago
Three Of 12 Patients Taking Pyridorin (Pyridoxamine Dihydrochloride) Convert From Macro- To Microalbuminuria
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By Maggie Schwarz
Special to DG News
PHILADELPHIA, PA -- November 3, 2002 -- The advanced glycation end product (AGE) inhibitor Pyridorin (pyridoxamine dihydrochloride) has potential in treating diabetic nephropathy, researchers reported here November 1 at the 35th Annual Meeting of the American Society of Nephrology (ASN).
Dr. Thorsten P. Degenhardt and colleagues from BioStratum Incorporated, in Durham, North Carolina, United States, conducted a randomised, placebo-controlled trial including 12 patients with type 2 diabetes and macroalbuminuria greater than 300 mg/day.
They randomised patients to receive Pyridorin or placebo at a 3 to 1 ratio and escalated the dose of Pyridorin based on tolerability, from 50 mg b.i.d. on days 1 through 7 to 250 mg b.i.d. on days 9 through 15, to 500 mg b.i.d. on days 17 through 44.
Pharmacokinetic assessments were performed after the first (0 to 12 hours) and last (0 to 48 hours) dose of each dosing level. After the first dose of each dosing level, the time of maximum concentration was approximately 2.5 hours. The maximum drug concentration was 1 and 1.5
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